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Article

Hi-Plex for high-throughput mutation screening: application to the breast cancer susceptibility gene PALB2.

BMC medical genomics - 8 Nov 2013

Nguyen-Dumont Tú, Teo Zhi L, Pope Bernard J, Hammet Fleur, Mahmoodi Maryam, Tsimiklis Helen, Sabbaghian Nelly, Tischkowitz Marc, Foulkes William D, Giles Graham G, Hopper John L, Southey Melissa C, Park Daniel J

Abstract excerpt

BACKGROUND: Massively parallel sequencing (MPS) has revolutionised biomedical research and offers enormous capacity for clinical application. We previously reported Hi-Plex, a streamlined highly-multiplexed PCR-MPS approach, allowing a given library to be sequenced with both the Ion Torrent and TruSeq chemistries. Comparable sequencing efficiency was achieved using material derived from lymphoblastoid cell lines...

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Share to Breast Neoplasms
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Fanconi Anemia Complementation Group N Protein

Share to Genetic Predisposition to Disease

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Source

Open in PubMed Open full text

Identifiers

PMID: 24206657
DOI: 10.1186/1755-8794-6-48
PMCID: PMC3829211

Genes

PALB2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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