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Article

A hidden Markov model for investigating recent positive selection through haplotype structure.

Theoretical population biology - 1 Feb 2015

Chen Hua, Hey Jody, Slatkin Montgomery

Abstract excerpt

Recent positive selection can increase the frequency of an advantageous mutant rapidly enough that a relatively long ancestral haplotype will be remained intact around it. We present a hidden Markov model (HMM) to identify such haplotype structures. With HMM identified haplotype structures, a population genetic model for the extent of ancestral haplotypes is then adopted for parameter inference of the selection...

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Identifiers

PMID: 25446961
DOI: 10.1016/j.tpb.2014.11.001
PMCID: PMC4277924

Genes

KITLG
LCT
OCA2
TYRP1

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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