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The highly prevalent H3F3A mutation in giant cell tumours of bone is not shared by sporadic central giant cell lesion of the jaws.

Oral surgery, oral medicine, oral pathology and oral radiology - 1 Nov 2014

Gomes Carolina Cavaliéri, Diniz Marina Gonçalves, Amaral Fabrício Rezende, Antonini Guimarães Bruna Viana, Gomez Ricardo Santiago

Abstract excerpt

OBJECTIVE: Central giant cell lesion (CGCL) and giant cell tumour (GCT) are bone lesions that share similar microscopic features. Recently, it was reported that 90% of bone GCT exhibit either p.Gly34 Trp or p.Gly34 Leu in H3F3A, one of two genes for histone H3.3 located on chromosome 1. We aimed to test whether sporadic CGCL of the jaws share the H3F3A mutations reported in GCT of other bones. METHODS: Nine...

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PMID: 25442495
DOI: 10.1016/j.oooo.2014.07.011

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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