Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Apelin/APJ: Another Player in the Cancer Biology Network

25 Mar 2025

Abstract excerpt

The apelinergic system exerts multiple biological activities in human pathologies, including cancer. Overactivation of apelin/APJ, which has been detected in many malignant tumors, and the strong correlation with progression-free and overall survival, suggested the role of an oncogene for the apelin gene. Emerging evidence sheds new light on the effects of apelin on cellular functions and homeostasis in cancer...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Nuclear Receptors and Signaling
Share to Apelin-related biomedical research
Share to Cardiovascular, Neuropeptides, and Oxidative Stress Research

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 40243599
DOI: 10.3390/ijms26072986

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Apelin/APJ: Another Player in the Cancer Biology NetworkPMID 40243599Read ↗

A network map of apelin-mediated signalingSemantic proximity Read ↗

A promising therapeutic peptide and preventive/diagnostic biomarker for age-related diseases: The Elabela/Apela/Toddler peptideSemantic proximity Read ↗

The Role of the Autonomic Nervous System in Oncogenesis: Friend or Foe?Semantic proximity Read ↗

Targeting drugs to APJ receptor: the prospect of treatment of hypertension and other cardiovascular diseases.Semantic proximity Read ↗

Pan‐cancer analysis of SERPINE1 with a concentration on immune therapeutic and prognostic in gastric cancerSemantic proximity Read ↗

ELA/APELA precursor cleaved by furin displays tumor suppressor function in renal cell carcinoma through mTORC1 activationSemantic proximity Read ↗

Downregulation of the Apelinergic Axis Accelerates Aging, whereas Its Systemic Restoration Improves the Mammalian HealthspanSemantic proximity Read ↗

Biochemical and genetic role of apelin in essential hypertension and acute coronary syndrome.Semantic proximity Read ↗

Characterization of Apelin, the Ligand for the APJ ReceptorSemantic proximity Read ↗

The p38 MAPK Components and Modulators as Biomarkers and Molecular Targets in CancerSemantic proximity Read ↗

ELABELA as a Potential Diagnostic Biomarker and Therapeutic Target of AtherosclerosisSemantic proximity Read ↗

APE1/Ref-1 – One Target with Multiple Indications: Emerging Aspects and New DirectionsSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.