Article
Single Nucleotide Polymorphisms of IL-33 Gene Correlated with Renal Allograft Fibrosis in Kidney Transplant Recipients.
Journal of immunology research - 1 Jan 2021
Liu Xuzhong, Liu Kun, Gui Zeping, Feng Dengyuan, Wang Zijie, Zheng Ming, Fei Shuang, Chen Hao, Sun Li, Han Zhijian, Ju Xiaobing, Zhang Hengcheng, Tan Ruoyun, Gu Min
Abstract excerpt
BACKGROUND: Nowadays, renal allograft survival is confined by the development of allograft fibrosis. Previous studies have reported interleukin-33 (IL-33) upregulated significantly in patients with chronic renal allograft dysfunction, and it could induce renal tubular epithelial to mesenchymal transition (EMT), which eventually contributed to renal allograft fibrosis. Our study intended to detect the underlying...
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