Article
Rare, nonsynonymous variant in the smooth muscle-specific isoform of myosin heavy chain, MYH11, R247C, alters force generation in the aorta and phenotype of smooth muscle cells.
Circulation research - 25 May 2012
Kuang Shao-Qing, Kwartler Callie S, Byanova Katerina L, Pham John, Gong Limin, Prakash Siddharth K, Huang Jian, Kamm Kristine E, Stull James T, Sweeney H Lee, Milewicz Dianna M
Abstract excerpt
RATIONALE: Mutations in myosin heavy chain (MYH11) cause autosomal dominant inheritance of thoracic aortic aneurysms and dissections. At the same time, rare, nonsynonymous variants in MYH11 that are predicted to disrupt protein function but do not cause inherited aortic disease are common in the general population and the vascular disease risk associated with these variants is unknown. OBJECTIVE: To determine the...
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