Article
Identifying functional gene regulatory network phenotypes underlying single cell transcriptional variability.
Progress in biophysics and molecular biology - 1 Jan 2015
Park James, Ogunnaike Babatunde, Schwaber James, Vadigepalli Rajanikanth
Abstract excerpt
Recent analysis of single-cell transcriptomic data has revealed a surprising organization of the transcriptional variability pervasive across individual neurons. In response to distinct combinations of synaptic input-type, a new organization of neuronal subtypes emerged based on transcriptional states that were aligned along a gradient of correlated gene expression. Individual neurons traverse across these...
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