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Article

A robust computational quest: Discovering potential hits to improve the treatment of pyrazinamide-resistant Mycobacterium tuberculosis.

Journal of cellular and molecular medicine - 1 Apr 2024

Shahab Muhammad, de Farias Morais Gabriel Christian, Akash Shopnil, Fulco Umberto Laino, Oliveira Jonas Ivan Nobre, Zheng Guojun, Akter Shahina

Abstract excerpt

The rise of pyrazinamide (PZA)-resistant strains of Mycobacterium tuberculosis (MTB) poses a major challenge to conventional tuberculosis (TB) treatments. PZA, a cornerstone of TB therapy, must be activated by the mycobacterial enzyme pyrazinamidase (PZase) to convert its active form, pyrazinoic acid, which targets the ribosomal protein S1. Resistance, often associated with mutations in the RpsA protein,...

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Identifiers

PMID: 38634203
DOI: 10.1111/jcmm.18279
PMCID: PMC11024510

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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