Article
Mutational analysis of the tyrosine kinome in serous and clear cell endometrial cancer uncovers rare somatic mutations in TNK2 and DDR1.
BMC cancer - 26 Nov 2014
Rudd Meghan L, Mohamed Hassan, Price Jessica C, O'Hara Andrea J, Le Gallo Matthieu, Urick Mary Ellen, Cruz Pedro, Zhang Suiyuan, Hansen Nancy F, Godwin Andrew K, Sgroi Dennis C, Wolfsberg Tyra G, Mullikin James C, Merino Maria J, Bell Daphne W
Abstract excerpt
BACKGROUND: Endometrial cancer (EC) is the 8th leading cause of cancer death amongst American women. Most ECs are endometrioid, serous, or clear cell carcinomas, or an admixture of histologies. Serous and clear ECs are clinically aggressive tumors for which alternative therapeutic approaches are needed. The purpose of this study was to search for somatic mutations in the tyrosine kinome of serous and clear cell...
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