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Article

Recombinant HIV envelope trimer selects for quaternary-dependent antibodies targeting the trimer apex.

Proceedings of the National Academy of Sciences of the United States of America - 9 Dec 2014

Sok Devin, van Gils Marit J, Pauthner Matthias, Julien Jean-Philippe, Saye-Francisco Karen L, Hsueh Jessica, Briney Bryan, Lee Jeong Hyun, Le Khoa M, Lee Peter S, Hua Yuanzi, Seaman Michael S, Moore John P, Ward Andrew B, Wilson Ian A, Sanders Rogier W, Burton Dennis R

Abstract excerpt

Broadly neutralizing antibodies (bnAbs) targeting the trimer apex of HIV envelope are favored candidates for vaccine design and immunotherapy because of their great neutralization breadth and potency. However, methods of isolating bnAbs against this site have been limited by the quaternary nature of the epitope region. Here we report the use of a recombinant HIV envelope trimer, BG505 SOSIP.664 gp140, as an...

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Identifiers

PMID: 25422458
DOI: 10.1073/pnas.1415789111
PMCID: PMC4267403

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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