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Article

Transcriptional profiling reveals functional links between RasGrf1 and Pttg1 in pancreatic beta cells.

BMC genomics - 25 Nov 2014

Manyes Lara, Arribas Monica, Gomez Carmela, Calzada Nuria, Fernandez-Medarde Alberto, Santos Eugenio

Abstract excerpt

BACKGROUND: Our prior characterization of RasGrf1 deficient mice uncovered significant defects in pancreatic islet count and size as well as beta cell development and signaling function, raising question about the mechanisms linking RasGrf1 to the generation of those "pancreatic" phenotypes. RESULTS: Here, we compared the transcriptional profile of highly purified pancreatic islets from RasGrf1 KO mice to that of...

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Identifiers

PMID: 25421944
DOI: 10.1186/1471-2164-15-1019
PMCID: PMC4301450

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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