The osteogenic or adipogenic lineage commitment of human mesenchymal stem cells is determined by protein kinase C delta

Abstract excerpt

BACKGROUND: Mesenchymal stem cells (MSCs) have the potential to differentiate into specialized cell lineages such as osteoblasts and adipocytes in vitro. There exists a reciprocal relationship between osteogenic and adipogenic differentiation of MSCs that an osteogenic phenotype occurs at the expense of an adipogenic phenotype and vice versa, which in turn influence one another's phenotype through negative...

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