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Article

Simulation and estimation of gene number in a biological pathway using almost complete saturation mutagenesis screening of haploid mouse cells.

BMC genomics - 24 Nov 2014

Tokunaga Masahiro, Kokubu Chikara, Maeda Yusuke, Sese Jun, Horie Kyoji, Sugimoto Nakaba, Kinoshita Taroh, Yusa Kosuke, Takeda Junji

Abstract excerpt

BACKGROUND: Genome-wide saturation mutagenesis and subsequent phenotype-driven screening has been central to a comprehensive understanding of complex biological processes in classical model organisms such as flies, nematodes, and plants. The degree of "saturation" (i.e., the fraction of possible target genes identified) has been shown to be a critical parameter in determining all relevant genes involved in a...

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Identifiers

PMID: 25418962
DOI: 10.1186/1471-2164-15-1016
PMCID: PMC4301880

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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