Screening for common mutations in BRCA1 and BRCA2 genes: interest in genetic testing of Tunisian families with breast and/or ovarian cancer.

doi:10.1684/bdc.2014.2049

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Article

Screening for common mutations in BRCA1 and BRCA2 genes: interest in genetic testing of Tunisian families with breast and/or ovarian cancer.

Bulletin du cancer - 1 Nov 2014

Fourati Asma, Louchez Marie-Michèle, Fournier Joelle, Gamoudi Amor, Rahal Khaled, El May Michèle-Véronique, El May Ahmed, Revillion Françoise, Peyrat Jean-Philippe

Abstract excerpt

BACKGROUND: In the Tunisian population, as yet a limited number of BRCA1/2 germline mutations have been reported in hereditary breast and/or ovarian cancer. These mutations are located in a few exons of BRCA1/2. The aim of the present study was to search for these mutations in 66 unrelated patients with hereditary breast and/or ovarian cancer in order to assess the interest in such a targeted approach for genetic...

Topics

Adult
Aged
Aged, 80 and over
Breast Neoplasms
Exons
Family Health
Female
Frameshift Mutation
Genes, BRCA1
Genes, BRCA2
Genetic Predisposition to Disease

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Genetic Testing

Germ-Line Mutation

Humans

Middle Aged

Ovarian Neoplasms

Polymorphism, Genetic

Triple Negative Breast Neoplasms

Source

Open in PubMed

Identifiers

PMID: 25418591
DOI: 10.1684/bdc.2014.2049

Genes

BRCA1
BRCA2

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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