Article
High frequency of the recurrent c.1310_1313delAAGA BRCA2 mutation in the North-East of Morocco and implication for hereditary breast-ovarian cancer prevention and control.
BMC research notes - 2 Jun 2017
Laarabi Fatima-Zahra, Ratbi Ilham, Elalaoui Siham Chafai, Mezzouar Loubna, Doubaj Yassamine, Bouguenouch Laila, Ouldim Karim, Benjaafar Noureddine, Sefiani Abdelaziz
Abstract excerpt
BACKGROUND: To date, a limited number of BRCA1/2 germline mutations have been reported in hereditary breast and/or ovarian cancer in the Moroccan population. Less than 20 different mutations of these two genes have been identified in Moroccan patients, and recently we reported a further BRCA2 mutation (c.1310_1313delAAGA; p.Lys437IlefsX22) in three unrelated patients, all from the North-East of the country. We...
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