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Contribution of BRCA1 5382insC mutation in triple negative breast cancer in Tunisia

11 Apr 2019

Abstract excerpt

BACKGROUND: Triple negative breast cancer (TNBC) has been classified as a disease subgroup defined by the lack of expression of estrogen and progesterone receptors as well as the absence of the human epidermal growth factor receptor-2 (HER2) overexpression. Germline mutations in the BRCA1 gene have been associated with TNBC. Approximately 70% of breast cancers arising in BRCA1 mutation carriers and up to 23% of...

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PMID: 30975216
DOI: 10.1186/s12967-019-1873-8

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