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Article

A highly tilted membrane configuration for the prefusion state of synaptobrevin.

Biophysical journal - 4 Nov 2014

Blanchard Andrew E, Arcario Mark J, Schulten Klaus, Tajkhorshid Emad

Abstract excerpt

The SNARE complex plays a vital role in vesicle fusion arising during neuronal exocytosis. Key components in the regulation of SNARE complex formation, and ultimately fusion, are the transmembrane and linker regions of the vesicle-associated protein, synaptobrevin. However, the membrane-embedded structure of synaptobrevin in its prefusion state, which determines its interaction with other SNARE proteins during...

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Identifiers

PMID: 25418096
DOI: 10.1016/j.bpj.2014.09.013
PMCID: PMC4223215

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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