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Article

Coarse-grain simulations reveal movement of the synaptobrevin C-terminus in response to piconewton forces.

Biophysical journal - 5 Sept 2012

Lindau Manfred, Hall Benjamin A, Chetwynd Alan, Beckstein Oliver, Sansom Mark S P

Abstract excerpt

Fusion of neurosecretory vesicles with the plasma membrane is mediated by SNARE proteins, which transfer a force to the membranes. However, the mechanism by which this force transfer induces fusion pore formation is still unknown. The neuronal vesicular SNARE protein synaptobrevin 2 (syb2) is anchored in the vesicle membrane by a single C-terminal transmembrane (TM) helix. In coarse-grain molecular-dynamics...

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Identifiers

PMID: 23009845
DOI: 10.1016/j.bpj.2012.08.007
PMCID: PMC3433613

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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