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Article

The oestrogen receptor alpha-regulated lncRNA NEAT1 is a critical modulator of prostate cancer

21 Nov 2014

Abstract excerpt

The androgen receptor (AR) plays a central role in establishing an oncogenic cascade that drives prostate cancer progression. Some prostate cancers escape androgen dependence and are often associated with an aggressive phenotype. The oestrogen receptor alpha (ERα) is expressed in prostate cancers, independent of AR status. However, the role of ERα remains elusive. Using a combination of chromatin...

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PMID: 25415230
DOI: 10.1038/ncomms6383

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