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Article

The Mtr4 ratchet helix and arch domain both function to promote RNA unwinding.

Nucleic acids research - 16 Dec 2014

Taylor Lacy L, Jackson Ryan N, Rexhepaj Megi, King Alejandra Klauer, Lott Lindsey K, van Hoof Ambro, Johnson Sean J

Abstract excerpt

Mtr4 is a conserved Ski2-like RNA helicase and a subunit of the TRAMP complex that activates exosome-mediated 3'-5' turnover in nuclear RNA surveillance and processing pathways. Prominent features of the Mtr4 structure include a four-domain ring-like helicase core and a large arch domain that spans the core. The 'ratchet helix' is positioned to interact with RNA substrates as they move through the helicase....

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Identifiers

PMID: 25414331
DOI: 10.1093/nar/gku1208
PMCID: PMC4267639

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