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Article

The role of the hypoxia response in shaping retinal vascular development in the absence of Norrin/Frizzled4 signaling.

Investigative ophthalmology & visual science - 20 Nov 2014

Rattner Amir, Wang Yanshu, Zhou Yulian, Williams John, Nathans Jeremy

Abstract excerpt

PURPOSE: To define the role of hypoxia and vascular endothelial growth factor (VEGF) in modifying the pattern, density, and permeability of the retinal vasculature in mouse models in which Norrin/Frizzled4 signaling is impaired. METHODS: Retinal vascular structure was analyzed in mice with mutation of Ndp (the gene coding for Norrin) or Frizzle4 (Fz4) with or without three additional perturbations: (1) retinal...

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Source

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Identifiers

PMID: 25414188
DOI: 10.1167/iovs.14-15693
PMCID: PMC4280883

Genes

NRP1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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