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Article

Fzd4 Haploinsufficiency Delays Retinal Revascularization in the Mouse Model of Oxygen Induced Retinopathy.

PloS one - 1 Jan 2016

Ngo Michael H, Borowska-Fielding Joanna, Heathcote Godfrey, Nejat Sara, Kelly Melanie E, McMaster Christopher R, Robitaille Johane M

Abstract excerpt

Mutations in genes that code for components of the Norrin-FZD4 ligand-receptor complex cause the inherited childhood blinding disorder familial exudative vitreoretinopathy (FEVR). Statistical evidence from studies of patients at risk for the acquired disease retinopathy of prematurity (ROP) suggest that rare polymorphisms in these same genes increase the risk of developing severe ROP, implying that decreased...

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Source

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Identifiers

PMID: 27489958
DOI: 10.1371/journal.pone.0158320
PMCID: PMC4973993

Genes

FZD4

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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Fzd4 Haploinsufficiency Delays Retinal Revascularization in the Mouse Model of Oxygen Induced Retinopathy.PMID 27489958Read ↗

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