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The pentameric complex is not required for vertical transmission of cytomegalovirus in seronegative pregnant rhesus macaques

2023-06-16

Abstract excerpt

Congenital cytomegalovirus (cCMV) infection is the leading infectious cause of neonatal neurological impairment but essential virological determinants of transplacental CMV transmission remain unclear. The pentameric complex (PC), composed of five subunits, glycoproteins H (gH), gL, UL128, UL130, and UL131A, is essential for efficient entry into non-fibroblast cells in vitro . Based on this role in cell tropism,...

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Literature Corpus work
1679a626-6a8f-593c-86c8-b3bcd3909a47
DOI
10.1101/2023.06.15.545169
Open publication

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