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Article

Changes in the proteomic profile during the differential polarization status of the human monocyte-derived macrophage THP-1 cell line.

Proteomics - 1 Feb 2015

Zhang Fan, Liu Hao, Jiang Guanmin, Wang Hongsheng, Wang Xianfeng, Wang Hao, Fang Rui, Cai Shaohui, Du Jun

Abstract excerpt

Macrophages are heterogeneous and plastic populations that are an essential component of inflammation and host defense. To understand how macrophages respond to cytokine signals, we used 2DE to identify protein profiles in macrophages stimulated with interleukin 4 (M2) and those stimulated with lipopolysaccharide and interferon γ (M1). In total, 32 differentially expressed proteins in THP-1 cells were identified...

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Identifiers

PMID: 25411139
DOI: 10.1002/pmic.201300494

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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