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Article

Hepatitis C virus nonstructural protein 5A inhibits thapsigargin-induced apoptosis.

PloS one - 1 Jan 2014

Jiang Xia, Kanda Tatsuo, Wu Shuang, Nakamoto Shingo, Wakita Takaji, Shirasawa Hiroshi, Yokosuka Osamu

Abstract excerpt

BACKGROUND: We previously reported that the hepatitis C virus (HCV) nonstructural protein 5A (NS5A) down-regulates TLR4 signaling and lipopolysaccharide-induced apoptosis of hepatocytes. There have been several reports regarding the association between HCV infection and endoplasmic reticulum (ER) stress. Here, we examined the regulation of HCV NS5A on the apoptosis of hepatocytes induced by thapsigargin, an...

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Identifiers

PMID: 25409163
DOI: 10.1371/journal.pone.0113499
PMCID: PMC4237446

Genes

TLR4
XIAP

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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