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Article

Suppression of a pro-apoptotic K <sup>+</sup> channel as a mechanism for hepatitis C virus persistence

26 Aug 2009

Abstract excerpt

An estimated 3% of the global population are infected with hepatitis C virus (HCV), and the majority of these individuals will develop chronic liver disease. As with other chronic viruses, establishment of persistent infection requires that HCV-infected cells must be refractory to a range of pro-apoptotic stimuli. In response to oxidative stress, amplification of an outward K(+) current mediated by the Kv2.1...

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PMID: 19717445
DOI: 10.1073/pnas.0906798106

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