Article
Convergent loss of PTEN leads to clinical resistance to a PI(3)Kα inhibitor.
Nature - 12 Feb 2015
Juric Dejan, Castel Pau, Griffith Malachi, Griffith Obi L, Won Helen H, Ellis Haley, Ebbesen Saya H, Ainscough Benjamin J, Ramu Avinash, Iyer Gopa, Shah Ronak H, Huynh Tiffany, Mino-Kenudson Mari, Sgroi Dennis, Isakoff Steven, Thabet Ashraf, Elamine Leila, Solit David B, Lowe Scott W, Quadt Cornelia, Peters Malte, Derti Adnan, Schegel Robert, Huang Alan, Mardis Elaine R, Berger Michael F, Baselga José, Scaltriti Maurizio
Abstract excerpt
Broad and deep tumour genome sequencing has shed new light on tumour heterogeneity and provided important insights into the evolution of metastases arising from different clones. There is an additional layer of complexity, in that tumour evolution may be influenced by selective pressure provided by therapy, in a similar fashion to that occurring in infectious diseases. Here we studied tumour genomic evolution in...
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