Article
PI3Kα inhibitors that inhibit metastasis.
Oncotarget - 1 Sept 2010
Schmidt-Kittler Oleg, Zhu Jiuxiang, Yang Jian, Liu Guosheng, Hendricks William, Lengauer Christoph, Gabelli Sandra B, Kinzler Kenneth W, Vogelstein Bert, Huso David L, Zhou Shibin
Abstract excerpt
Previous genetic analyses have suggested that mutations of the genes encoding PI3Kα facilitate invasion and metastasis but have less effect on primary tumor growth. These findings have major implications for therapeutics but have not been factored into pre-clinical drug development designs. Here...
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