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Article

Molecular phenotypes associated with antipsychotic drugs in the human caudate nucleus.

Molecular psychiatry - 1 Apr 2022

Perzel Mandell Kira A, Eagles Nicholas J, Deep-Soboslay Amy, Tao Ran, Han Shizhong, Wilton Richard, Szalay Alexander S, Hyde Thomas M, Kleinman Joel E, Jaffe Andrew E, Weinberger Daniel R

Abstract excerpt

Antipsychotic drugs are the current first-line of treatment for schizophrenia and other psychotic conditions. However, their molecular effects on the human brain are poorly studied, due to difficulty of tissue access and confounders associated with disease status. Here we examine differences in gene expression and DNA methylation associated with positive antipsychotic drug toxicology status in the human caudate...

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Identifiers

PMID: 35236959
DOI: 10.1038/s41380-022-01453-6
PMCID: PMC9133054

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