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Article

A primary melanoma and its asynchronous metastasis highlight the role of BRAF, CDKN2A, and TERT.

Journal of cutaneous pathology - 1 Feb 2015

Hosler Gregory A, Davoli Teresa, Mender Ilgen, Litzner Brandon, Choi Jaehyuk, Kapur Payal, Shay Jerry W, Wang Richard C

Abstract excerpt

BACKGROUND: Alterations in pathways including BRAF, CDKN2A, and TERT contribute to the development of melanoma, but the sequence in which the genetic alterations occur and their prognostic significance remains unclear. To clarify the role of these pathways, we analyzed a primary melanoma and its metastasis. METHODS: Immunohistochemistry for BRAF-V600E, Sanger sequencing of BRAF and the TERT promoter, fluorescence...

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Source

Open in PubMed Open full text

Identifiers

PMID: 25407517
DOI: 10.1111/cup.12444
PMCID: PMC4470704

Genes

BRAF
TERT

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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