Increased Culture Density Is Linked to Decelerated Proliferation, Prolonged G 1 Phase, and Enhanced Propensity for Differentiation of Self-Renewing Human Pluripotent Stem Cells

Abstract excerpt

Human pluripotent stem cells (hPSCs) display a very short G1 phase and rapid proliferation kinetics. Regulation of the cell cycle, which is linked to pluripotency and differentiation, is dependent on the stem cell environment, particularly on culture density. This link has been so far empirical and central to disparities in the growth rates and fractions of self-renewing hPSCs residing in different cycle phases....

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