Article
Leptin-mediated increases in catecholamine signaling reduce adipose tissue inflammation via activation of macrophage HDAC4.
Cell metabolism - 3 Jun 2014
Luan Bing, Goodarzi Mark O, Phillips Naomi G, Guo Xiuqing, Chen Yii-Der I, Yao Jie, Allison Matthew, Rotter Jerome I, Shaw Reuben, Montminy Marc
Abstract excerpt
Obesity promotes systemic insulin resistance through inflammatory changes that lead to the release of cytokines from activated macrophages. Although the mechanism is unclear, the second messenger cAMP has been found to attenuate macrophage activity in response to a variety of hormonal signals. We show that, in the setting of acute overnutrition, leptin triggers catecholamine-dependent increases in cAMP signaling...
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