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Targeting HER proteins in cancer therapy and the role of the non-target HER3

31 Jul 2007

Abstract excerpt

Members of the human epidermal growth factor receptor (HER) family have been of considerable interest in the cancer arena due to their potential to induce tumorigenesis when their signalling functions are deregulated. The constitutive activation of these proteins is seen in a number of different common cancer subtypes, and in particular EGFR and HER2 have become highly pursued targets for anti-cancer drug...

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PMID: 17667926
DOI: 10.1038/sj.bjc.6603910

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