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Article

Protein engineering of Cas9 for enhanced function.

Methods in enzymology - 1 Jan 2014

Oakes Benjamin L, Nadler Dana C, Savage David F

Abstract excerpt

CRISPR/Cas systems act to protect the cell from invading nucleic acids in many bacteria and archaea. The bacterial immune protein Cas9 is a component of one of these CRISPR/Cas systems and has recently been adapted as a tool for genome editing. Cas9 is easily targeted to bind and cleave a DNA seq...

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Identifiers

PMID: 25398355
DOI: 10.1016/B978-0-12-801185-0.00024-6
PMCID: PMC4641071

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-25398355-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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