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Essential nutrient supplementation prevents heritable metabolic disease in multigenerational intrauterine growth‐restricted rats

13 Nov 2014

Abstract excerpt

Intrauterine growth restriction (IUGR) confers heritable alterations in DNA methylation, rendering risk of adult metabolic syndrome (MetS). Because CpG methylation is coupled to intake of essential nutrients along the one‐carbon pathway, we reasoned that essential nutrient supplementation (ENS) may abrogate IUGR‐conferred multigenerational MetS. Pregnant Sprague‐Dawley rats underwent bilateral uterine artery...

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PMID: 25395450
DOI: 10.1096/fj.14-259614

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