Article
IUGR with infantile overnutrition programs an insulin-resistant phenotype through DNA methylation of peroxisome proliferator-activated receptor-γ coactivator-1α in rats.
Pediatric research - 1 May 2015
Xie Xuemei, Lin Tulian, Zhang Meihui, Liao Lihong, Yuan Guandou, Gao Hongjie, Ning Qin, Luo Xiaoping
Abstract excerpt
BACKGROUND: Intrauterine growth restriction (IUGR) followed by postnatal accelerated growth (CG-IUGR) is associated with long-term adverse metabolic consequences, and an involvement of epigenetic dysregulation has been implicated. Peroxisome proliferator-activated receptor-γ coactivator-1α (PGC-1α) is a key orchestrator in energy homeostasis. We hypothesized that CG-IUGR programed an insulin-resistant phenotype...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.