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Maternal vitamin B12 deficiency in rats alters DNA methylation in metabolically important genes in their offspring.

Molecular and cellular biochemistry - 1 May 2020

Tanwar Vinay Singh, Ghosh Sourav, Sati Satish, Ghose Subhoshree, Kaur Lovejeet, Kumar Kalle Anand, Shamsudheen K V, Patowary Ashok, Singh Meghna, Jyothi V, Kommineni Pujitha, Sivasubbu Sridhar, Scaria Vinod, Raghunath Manchala, Mishra Rakesh, Chandak Giriraj Ratan, Sengupta Shantanu

Abstract excerpt

Vitamin B12 deficiency is a critical problem worldwide and peri-conceptional deficiency of this vitamin is associated with the risk of complex cardio-metabolic diseases. Nutritional perturbations during these stages of development may lead to changes in the fetal epigenome. Using Wistar rat model system, we have earlier shown that low maternal B12 levels are associated with low birth weight, adiposity, insulin...

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PMID: 32189172
DOI: 10.1007/s11010-020-03713-x

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