Choline insufficiency in mothers during gestation abolishes the metabolically restrained hepatic phenotype induced by gestational protein restriction and promotes hepatic steatosis in offspring.

Abstract excerpt

Maternal protein restriction during gestation in rodents is widely used as a model of developmental programming; however, its metabolic effects in offspring are often modest. In humans, protein deficiency is frequently accompanied by deficiencies in essential micronutrients. This study examined whether maternal choline insufficiency, an essential micronutrient whose deficiency in adult rodents induces metabolic...

Topics

• Animals
• Female
• Pregnancy
• Choline Deficiency
• Liver
• Fatty Liver