Article
Zinc supplementation inhibits complement activation in age-related macular degeneration.
PloS one - 1 Jan 2014
Smailhodzic Dzenita, van Asten Freekje, Blom Anna M, Mohlin Frida C, den Hollander Anneke I, van de Ven Johannes P H, van Huet Ramon A C, Groenewoud Joannes M M, Tian Yuan, Berendschot Tos T J M, Lechanteur Yara T E, Fauser Sascha, de Bruijn Chris, Daha Mohamed R, van der Wilt Gert Jan, Hoyng Carel B, Klevering B Jeroen
Abstract excerpt
UNLABELLED: Age-related macular degeneration (AMD) is the leading cause of blindness in the Western world. AMD is a multifactorial disorder but complement-mediated inflammation at the level of the retina plays a pivotal role. Oral zinc supplementation can reduce the progression of AMD but the precise mechanism of this protective effect is as yet unclear. We investigated whether zinc supplementation directly...
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