Article
Polymorphisms in TP53 are associated with risk and survival of osteosarcoma in a Chinese population.
International journal of clinical and experimental pathology - 1 Jan 2015
Ru Jiang-Ying, Cong Yu, Kang Wen-Bo, Yu Lei, Guo Tin, Zhao Jian-Ning
Abstract excerpt
Osteosarcoma (OS) is the most frequent histological form of primary bone cancer in adolescence. TP53 is a tumor suppressor gene which is essential for regulating cell division and preventing tumor formation. The purpose of this study is to examine whether genetic mutations in the TP53 gene are associated with OS risk and survival in a Chinese population. Five polymorphisms in the TP53 gene were selected in a...
Topics
- Adolescent
- Adult
- Asian People
- Bone Neoplasms
- Case-Control Studies
- Child
- Female
- Genetic Predisposition to Disease
- Genotype
- Humans
- Male
- Osteosarcoma
- Polymerase Chain Reaction
- Polymorphism, Single Nucleotide