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Article

Monoamine oxidase A variants are associated with heavy betel quid use.

Addiction biology - 1 Jul 2012

Chen Ping-Ho, Tu Hung-Pin, Wang Shu-Jung, Ko Albert Min-Shan, Lee Chi-Pin, Chiang Tai-An, Tsai Yi-Shan, Lee Chien-Hung, Shieh Tien-Yu, Ko Chih-Hung, Chiang Shang-Lun, Ko Ying-Chin

Abstract excerpt

Few studies have investigated whether genetic abnormalities predispose individuals to heavy betel quid (BQ) use. One of the major ingredients of BQ, arecoline, is known to affect the expression of monoamine oxidase A (MAO-A). We investigated the extent to which arecoline inhibits MAO-A expression and the role of MAO-A polymorphisms in BQ use in Taiwanese aborigines. Cytotoxicity assays, microarrays and...

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Alcohol Drinking
Areca
Cell Survival
Genetic Loci
Monoamine Oxidase

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Substance-Related Disorders

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PMID: 21521428
DOI: 10.1111/j.1369-1600.2011.00331.x

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