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Article

Interplay between RNA-binding protein HuR and Nox4 as a novel therapeutic target in diabetic kidney disease

28 Feb 2020

Abstract excerpt

OBJECTIVE: Glomerular injury is a prominent pathological feature of diabetic kidney disease (DKD). Constitutively active NADPH oxidase 4 (Nox4) is a major source of reactive oxygen species that mediates hyperglycemia-induced mesangial cell (MC) fibrotic injury. However, the mechanism that Nox4 utilizes to achieve its biological outcome remains elusive, and the signaling pathways that regulate this isoform oxidase...

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PMID: 32240965
DOI: 10.1016/j.molmet.2020.02.011

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