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Article

Gender specific association of a complement component 3 polymorphism with polypoidal choroidal vasculopathy.

Scientific reports - 12 Nov 2014

Liu Ke, Lai Timothy Y Y, Chiang Sylvia W Y, Chan Vesta C K, Young Alvin L, Tam Pancy O S, Pang Chi Pui, Chen Li Jia

Abstract excerpt

Neovascular age-related macular degeneration (AMD) and polypoidal choroidal vasculopathy (PCV) are leading causes of irreversible blindness in developed countries. In this study, we investigated the associations of haplotype-tagging single nucleotide polymorphisms (SNPs) in the complement component 3 (C3) gene with both neovascular AMD and PCV, and potential epistatic effects on C3. Eight tagging SNPs in C3 were...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 25388911
DOI: 10.1038/srep07018
PMCID: PMC4228406

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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