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Article

Associations of 6p21.3 Region with Age-related Macular Degeneration and Polypoidal Choroidal Vasculopathy.

Scientific reports - 10 Feb 2016

Ye Zimeng, Shuai Ping, Zhai Yaru, Li Fang, Jiang Lingxi, Lu Fang, Wen Feng, Huang Lulin, Zhang Dingding, Liu Xiaoqi, Lin Ying, Luo Huaichao, Zhang Houbin, Zhu Xianjun, Wu Zhengzheng, Yang Zhenglin, Gong Bo, Shi Yi

Abstract excerpt

Neovascular age-related macular degeneration (AMD) and polypoidal choroidal vasculopathy (PCV) are leading causes of blindness in aging populations. This study was conducted to investigate the associations of chromosome 6p21.3 region, including CFB-SKIV2L-TNXB-FKBPL-NOTCH4 genes, with both neovascular AMD and PCV. Six single nucleotide polymorphisms (SNPs) in this region and two known AMD-associated SNPs in CFH...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 26861912
DOI: 10.1038/srep20914
PMCID: PMC4748259

Genes

FKBPL
TNXB
CFB
CFH
HTRA1
NOTCH4

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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