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Clostridium difficile Isolates with High Linezolid MICs Harbor the Multiresistance Gene <i>cfr</i>

11 Nov 2014

Abstract excerpt

We studied the molecular mechanisms of linezolid resistance in 9 isolates of toxigenic Clostridium difficile with high linezolid MICs. The activity of linezolid was determined against 891 clinical isolates of toxigenic C. difficile. The MIC50 and MIC90 of linezolid were 0.75 μg/ml and 1.5 μg/ml, respectively. Nine strains (1%) showed high linezolid MICs (6 μg/ml to 16 μg/ml) and also were resistant to...

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PMID: 25385106
DOI: 10.1128/aac.04082-14

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