Article
Tigecycline Nonsusceptibility Occurs Exclusively in Fluoroquinolone-Resistant Escherichia coli Clinical Isolates, Including the Major Multidrug-Resistant Lineages O25b:H4-ST131-H30R and O1-ST648.
Antimicrobial agents and chemotherapy - 1 Feb 2017
Sato Toyotaka, Suzuki Yuuki, Shiraishi Tsukasa, Honda Hiroyuki, Shinagawa Masaaki, Yamamoto Soh, Ogasawara Noriko, Takahashi Hiroki, Takahashi Satoshi, Tamura Yutaka, Yokota Shin-Ichi
Abstract excerpt
Tigecycline (TGC) is a last-line drug for multidrug-resistant Enterobacteriaceae We investigated the mechanism(s) underlying TGC nonsusceptibility (TGC resistant/intermediate) in Escherichia coli clinical isolates. The MIC of TGC was determined for 277 fluoroquinolone-susceptible isolates (ciprofloxacin [CIP] MIC, <0.125 mg/liter) and 194 fluoroquinolone-resistant isolates (CIP MIC, >2 mg/liter). The MIC50 and...
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