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Article

Targeting Hippo pathway by specific interruption of YAP-TEAD interaction using cyclic YAP-like peptides.

FASEB journal : official publication of the Federation of American Societies for Experimental Biology - 1 Feb 2015

Zhou Zheng, Hu Taishan, Xu Zhiheng, Lin Zhaohu, Zhang Zhisen, Feng Teng, Zhu Liangcheng, Rong Yiping, Shen Hong, Luk John M, Zhang Xiongwen, Qin Ning

Abstract excerpt

Hippo signaling pathway is emerging as a novel target for anticancer therapy because it plays key roles in organ size control and tumorigenesis. As the downstream effectors, Yes-associated protein (YAP)-transcriptional enhancer activation domain family member (TEAD) association is essential for YAP-driven oncogenic activity, while TEAD is largely dispensable for normal tissue growth. We present the design of...

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Source

Identifiers

PMID: 25384421
DOI: 10.1096/fj.14-262980

Genes

TEAD1

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Research trail→

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Targeting Hippo pathway by specific interruption of YAP-TEAD interaction using cyclic YAP-like peptides.PMID 25384421Read ↗

Discovery of a new class of reversible TEA-domain transcription factor inhibitors with a novel binding modeSemantic proximity Read ↗

An improved TEAD dominant-negative protein inhibitor to study Hippo YAP1/TAZ-dependent transcriptionSemantic proximity Read ↗

Targeted degradation of specific TEAD paralogs by small molecule degradersSemantic proximity Read ↗

Direct and selective pharmacological disruption of the YAP–TEAD interface by IAG933 inhibits Hippo-dependent and RAS–MAPK-altered cancersSemantic proximity Read ↗

Structure-based discovery of a novel small-molecule inhibitor of TEAD palmitoylation with anticancer activitySemantic proximity Read ↗

Structure-based optimization of TEAD inhibitors: Exploring a novel subpocket near Glu347 for the treatment of NF2-mutant cancer.Semantic proximity Read ↗

Genetic and pharmacological disruption of the TEAD-YAP complex suppresses the oncogenic activity of YAP.Semantic proximity Read ↗

A Novel Irreversible TEAD Inhibitor, SWTX-143, Blocks Hippo Pathway Transcriptional Output and Causes Tumor Regression in Preclinical Mesothelioma ModelsSemantic proximity Read ↗

Targeting the Hippo pathway in cancers via ubiquitination dependent TEAD degradationSemantic proximity Read ↗

A coordinated phosphorylation by Lats and CK1 regulates YAP stability through SCF(beta-TRCP).Semantic proximity Read ↗

Functional imaging and targeted drug delivery in mice and patient tumors with a cell nucleolus-localizing and tumor-targeting peptideSemantic proximity Read ↗

Integration of Hippo signalling and the unfolded protein response to restrain liver overgrowth and tumorigenesis.Semantic proximity Read ↗

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