Article
The miR-184 binding-site rs8126 T>C polymorphism in TNFAIP2 is associated with risk of gastric cancer.
PloS one - 1 Jan 2013
Xu Yu, Ma Hongxia, Yu Hongping, Liu Zhensheng, Wang Li-E, Tan Dongfeng, Muddasani Ramya, Lu Victoria, Ajani Jaffer A, Wang Yanong, Wei Qingyi
Abstract excerpt
BACKGROUND: TNFAIP2 is a crucial gene involved in apoptosis. Single nucleotide polymorphisms (SNPs) in its miRNA binding sites could modulate functions of the miRNA-target genes and thus risk of cancers. In this study, we investigated associations between potentially functional SNPs in the miRNA binding sites of the 3'UTR of TNFAIP2 and gastric cancer risk in a US population. METHODS: We conducted a case-control...
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