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Article

Adipose tissue insulin receptor knockdown via a new primate-derived hybrid recombinant AAV serotype

1 Jan 2014

Abstract excerpt

Adipose tissue plays an essential role in metabolic homeostasis and holds promise as an alternative depot organ in gene therapy. However, efficient methods of gene transfer into adipose tissue in vivo have yet to be established. Here, we assessed the transduction efficiency to fat depots by a family of novel engineered hybrid capsid serotypes (Rec1∼4) recombinant adeno-associated viral (AAV) vectors in comparison...

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PMID: 25383359
DOI: 10.1038/mtm.2013.8

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