Article

Subcutaneous administration of adipose-tropic gene therapy for congenital leptin deficiency

2025-07-17

Abstract excerpt

<title>Abstract</title> <p>AAV-based gene therapy targeting adipose tissue has been underdeveloped due to lack of adipose-tropic AAV vectors with sufficient transduction efficiency. We previously demonstrated that an engineered capsid variant of Rec2 capsid with F503Y, Y708D and K709I substitution (named V7 capsid) exhibited highly selective adipo-tropism while ablating liver transduction upon intraperitoneal inj...

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Literature Corpus work: cd348cd6-106f-5fe0-beae-db4065a67708
DOI: 10.21203/rs.3.rs-7030870/v1

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